The best places to live in South Carolina for 2026-2027 are ranked based on value, desirability, job market, and quality of life. Top cities include Mount Pleasant, Greenville, Florence, Charleston, and Sumter. Mount Pleasant leads with strong job opportunities and community but has high housing costs. Greenville offers a booming job market and affordable living. Florence and Sumter are noted for affordability despite weaker job markets. Other notable cities are Rock Hill, Columbia, Hilton Head, Spartanburg, North Charleston, and Myrtle Beach.