Pittsburgh is the cheapest U.S. city to live in, with a median home price of $250,000, over $150,000 below the national median. Its affordability stems from steady demand, solid but older housing stock, and stable industries like healthcare, technology, and education. Other affordable cities include Decatur, IL, and Oklahoma City. Pittsburgh's balanced market attracts buyers and investors, offering a quality lifestyle with big-city amenities and a friendly community.