The most expensive homes in Missouri are primarily in the St. Louis metro area, with Huntleigh leading at a typical home value of $2.52 million. Other high-value cities include Village of Loch Lloyd ($1.37M) and Ladue ($1.37M). Kansas City and Springfield metros also feature but with lower values. Home prices have generally increased over five years, with some cities seeing over 40% growth. Mortgage rates are around 6.52%, impacting affordability.