First-time homebuyers in Canada should determine their budget, get pre-approved for a mortgage, and estimate upfront costs including down payment (5-20%), closing costs (2-4%), CMHC insurance if under 20% down, legal fees, land transfer tax, property tax, home insurance, and moving expenses. Building a real estate team and understanding the local market are crucial. Various federal and provincial programs offer financial assistance, such as tax credits, rebates, and down payment loans.